The sensor technology is still a long way from decoupling psychedelic medicine from hallucinatory side effects, cautions Robert Malenka, a psychiatrist and neuroscientist at Stanford University in California. Clarification 03 May : An earlier version of this story implied that David Olson's team was responsible for the fluorescent sensor that indicates whether hallucinations occur. It was Lin Tian's team that designed the sensor.
Dong, C. Article Google Scholar. Download references. Editorial 07 OCT News 27 SEP Comment 26 SEP News Explainer 10 NOV World View 09 NOV Outlook 27 OCT Technology Feature 09 NOV Research Highlight 29 OCT Francis Crick Institute. Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.
Advanced search. Skip to main content Thank you for visiting nature. Already a subscriber? Sign in. Thanks for reading Scientific American. Create your free account or Sign in to continue. See Subscription Options. Discover World-Changing Science. Zeroing in on a group of cells in a high layer of the cortex, a team of researchers from Mount Sinai School of Medicine, Columbia University and the New York State Psychiatric Institute may finally have found the cause of the swirling textures, blurry visions and signal-crossing synesthesia brought on by hallucinogenic drugs like LSD, peyote and "'shrooms.
Get smart. Unlike most other hallucinogens, DMT does not appear to induce tolerance Winstock, As with some other hallucinogens, there is little information to suggest that ayahuasca use creates lasting physiological or neurological deficits, especially among those using the brew for religious activities.
Overall, two long-term effects—persistent psychosis and HPPD—have been associated with use of classic hallucinogens see text box below. Although occurrence of either is rare, it is also unpredictable and may happen more often than previously thought, and sometimes both conditions occur together. While the exact causes are not known, both conditions are more often seen in individuals with a history of psychological problems but can happen to anyone, even after a single exposure.
There is no established treatment for HPPD, in which flashbacks may occur spontaneously and repeatedly although less intensely than their initial occurrence.
Some antidepressant and antipsychotic drugs can be prescribed to help improve mood and treat psychoses, however. Psychotherapy may also help patients cope with fear or confusion associated with visual disturbances or other consequences of long-term LSD use.
More research on the causes, incidence, and long-term effects of both disorders is being conducted. National Institutes of Health. Drug Topics.
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