Prozac effects which neurotransmitter

Suddenly stopping an antidepressant that has been used for 6 weeks or more can lead to withdrawal syndrome. Reducing intake can sometimes have this effect. Some patients do not experience withdrawal symptoms, while others will experience symptoms if they stop over several weeks. Some patients may need to stop suddenly, for example, due to adverse effects or pregnancy.

It is important for the patient and their doctor to discuss how to stop using fluoxetine. Prozac is selective serotonin reuptake inhibitor SSRI. It works by blocking the absorption of the neurotransmitter serotonin in the brain. Regulating the amount of serotonin helps brain cells transmit messages to each other. This results in a better and more stable mood. The hippocampus plays a role in forming memories.

The U. Food and Drug Administration FDA currently approves Prozac for acute and maintenance treatment of major depressive disorder MDD , obsessive compulsive disorder OCD , bulimia nervosa, and panic disorder, with or without agoraphobia. Prozac is normally used alone.

However, fluoxetine combined with olanzapine OFC can also be used to treat depressive episodes in people with bipolar disorder. Fluoxetine combined with olanzapine is known as Symbyax. This combination can also help people with treatment-resistant depression. Prozac can be used to treat depression in adults.

It can also be used for children and adolescents from the age of 10 to 19 years with severe, persistent depression. A review comparing the effectiveness of Prozac with other antidepressants found that it appears to be similarly effective, and possibly better tolerated. However, the authors concluded that more research is needed, as a number of factors made an exact comparison difficult.

Prefrontal cortex extracellular concentrations of fluoxetine at the dose that increased extracellular monoamines were nM, a concentration sufficient to block 5-HT 2C receptors which is a potential mechanism for the fluoxetine-induced increase in catecholamines.

Conclusion: Amongst the SSRIs examined, only fluoxetine acutely increases extracellular concentrations of norepinephrine and dopamine as well as serotonin in prefrontal cortex, suggesting that fluoxetine is an atypical SSRI. Richelson E. J Clin Psychopharmacol 16 Suppl 2 :1s—9s. Comparison of mania and depression. Psychiatry Res 61 : 1— Br J Psychiatry : — Stahl SM.

Serotonin receptors and pathways mediate therapeutic effects and side effects. J Affect Disord 51 : — Stein DJ, Hollander E. CNS Drugs 2 : 78— Stefanski R, Goldberg SR. CNS Drugs 7 : — Biol Psychiatry 43 : — Lancet 19 : Westenberg HG. J Clin Psychiatry 60 : 4—8. J Pharmacol Exp Ther : 61— Neuropsychopharmacology 8 : — Life Sci 57 : — Biol Psychiatry 47 : — Prog Neuropsychopharmacol Biol Psychiatry 21 : — Prog Neuropsychopharmacol Biol Psychiatry 22 : — Mol Pharmacol 40 : — Download references.

Susanne Koch Ph. You can also search for this author in PubMed Google Scholar. Reprints and Permissions. Koch, S. Neuropsychopharmacol 27, — Download citation. Received : 25 January Revised : 10 April Accepted : 17 April Published : 17 May Issue Date : 01 December Anyone you share the following link with will be able to read this content:. Sorry, a shareable link is not currently available for this article. Provided by the Springer Nature SharedIt content-sharing initiative. Environmental Science and Pollution Research Translational Psychiatry Molecular Neurobiology Psychopharmacology BMC Genomics Advanced search.

Skip to main content Thank you for visiting nature. Download PDF. Abstract The selective serotonin reuptake inhibitor fluoxetine consists of equal amounts of R and S stereoisomers. Probe Implantation The microdialysis technique has been previously described Li et al. Figure 1. Full size image. Figure 2. Make sure your doctor is aware of all prescription, over-the-counter, and natural remedies you use. Always seek professional advice before taking anything new while taking fluoxetine.

Avoid alcohol and sedatives. Drowsiness or nervousness may occur, particularly when you first start taking it fluoxetine. If you're having side effects from your medication, contact your doctor immediately. Avoid driving and operating heavy machinery until you know how you react to the medication.

Fluoxetine can cause a variety of side effects, including, but not limited to:. Ever wonder what your personality type means? Sign up to find out more in our Healthy Mind newsletter.

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