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Reprints are not available from the author. Interventions for paracetamol acetaminophen overdose. Cochrane Database Syst Rev. Dekhuijzen PN. Antioxidant properties of N -acetylcysteine: their relevance in relation to chronic obstructive pulmonary disease. Eur Respir J. Cytoprotection against oxidative stress and the regulation of glutathione synthesis.
Biol Chem. Effect of transdermal nitroglycerin or N -acetylcysteine, or both, in the long-term treatment of unstable angina pectoris. J Am Coll Cardiol.
Acetylcysteine Fabrol in chronic bronchitis—a study in general practice. J Int Med Res. Possible effect of acetylcysteine on lung function. The effect of oral N -acetylcysteine in chronic bronchitis: a quantitative systematic review. N -acetylcysteine for the prevention of contrast-induced nephropathy. A systematic review and meta-analysis. J Gen Intern Med. Incidence and prognostic importance of acute renal failure after percutaneous coronary intervention. Prevention of radiographic-contrast-agent-induced reductions in renal function by acetylcysteine.
N Engl J Med. Acetylcysteine in the prevention of contrast-induced nephropathy: a case study of the pitfalls in the evolution of evidence. Arch Intern Med. N -acetylcysteine and contrast-induced nephropathy: a meta-analysis of 13 randomized trials.
Am Heart J. Efficacy of N -acetyl-cysteine and hydration versus placebo and hydration in decreasing contrast-induced renal dysfunction in patients undergoing coronary angiography with or without concomitant percutaneous coronary intervention.
Heart Lung. A meta-analysis of N -acetylcysteine in contrast-induced nephrotoxicity: unsupervised clustering to resolve heterogeneity. BMC Med. N -acetylcysteine and contrast-induced nephropathy in primary angioplasty. Prevention of contrast-induced nephropathy: a critical review. Curr Opin Nephrol Hypertens. It has been used as a beneficial drug treatment for some disorders such as poly cystic ovary syndrome patients with CC resistance, preterm birth, acetaminophen toxicity, RPL, chronic bronchitis, ulcerative colitis, liver cancer, muscle performance, hemodialysis, asthma, Alzheimer and Parkinson.
Although in some cases, such as improving pregnancy rate in ICSI cycles, NAC action is still unclear and further investigations are necessary. The authors would like to thank Royan Institute experts for their helpful comments and suggestions. There is no conflict of interest in this study. National Center for Biotechnology Information , U. Journal List Cell J v. Cell J. Published online Dec Vida Mokhtari , M. Sc, 1, 2, 3 Parvaneh Afsharian , Ph. D, 2 Maryam Shahhoseini , Ph. D, 2 Seyed Mehdi Kalantar , Ph.
D, 1 and Ashraf Moini , M. Author information Article notes Copyright and License information Disclaimer. Received Dec 19; Accepted May 7. Copyright Any use, distribution, reproduction or abstract of this publication in any medium, with the exception of commercial purposes, is permitted provided the original work is properly cited. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
This article has been cited by other articles in PMC. Abstract N-acetyl cysteine NAC , as a nutritional supplement, is a greatly applied antioxidant in vivo and in vitro. Introduction N-acetyl cysteine NAC , as a safe and inexpensive medication, is commercially accessible since long-time ago 1. Premature birth and recurrent pregnancy loss Premature birth is the most common reason of perinatal mortality and long-term unhealthiness in low-income countries Acetaminophen toxicity Acetaminophen administration is reported as the most common drug overdose in pregnancy.
Administration of N-acetyl cysteine for infertile patients undergoing assisted reproductive techniques Elgindy et al. Chronic bronchitis Chronic bronchitis is defined as the presence of chronic productive cough for more than three months in each of two sequential years.
Ulcerative colitis Ulcerative colitis is a chronic inflammatory disorder which multiple casual factors can affect it. Liver cancer Liver cancer is one of the most common lifethreatening malignancies, all over the world and up to now, there is no effective drug for the treatment of liver tumors Hemodialysis Homocysteine Hcy is a sulphur-containing amino acid that is produced in body, by the metabolism of the methionine amino acid Asthma Asthma is a chronic disorder associated with inflammation and immune cell infiltration of airways Alzheimer Alzheimer disease AD is known as a multifactorial disease with many abnormalities in physiological, biochemical, and neurochemical point of view.
Parkinson Parkinson disease PD is a very prevalent neurodegenerative disorder caused by unknown deterioration of cells which generate dopamine in the pars compacta, a part of the substantial nigra located in the midbrain Conclusion A review on NAC literature shows that this agent is a safe and well-tolerated supplementary drug without any considerable side effects.
Acknowledgments The authors would like to thank Royan Institute experts for their helpful comments and suggestions. References 1. N-acetyl-cysteine in anovulatory women: the impact of postcoital test. Middle East Fertil Soc J. Dietary cysteine and other amino acids and stroke incidence in women.
Effect of oral N-acetyl cysteine on recurrent preterm labor following treatment for bacterial vaginosis. Int J Gynaecol Obstet. N-acetyl cysteine for treatment of recurrent unexplained pregnancy loss. Reprod Biomed Online. N-acetyl cysteine: could it be an effective adjuvant therapy in ICSI cycles?.
A preliminary study. Oxidants and antioxidants in human fertility. Protective effects of N-acetyl cysteine on acetic acid-induced colitis in a porcine model.
BMC Gastroenterol. Nasr A. Effect of N-acetyl cysteine after ovarian drilling in clomiphene citrate-resistant PCOS women: a pilot study. Association of thrombophilia and polycystic ovarian syndrome in women with history of recurrent pregnancy loss. Gynecol Eendocrinol. Prevalence of metabolic syndrome in polycystic ovarian syndrome women in a hospital of Tehran.
Iran J Reprod Med. Moini A, Eslami B. Familial associations between polycystic ovarian syndrome and common diseases. J Assist Reproduction Genet. Female infertility and antioxidants. Curr Womens Health Rev. Woods JR. Reactive oxygen species and preterm premature rupture of membranes a review.
The preterm prediction study: a clinical risk assessment system. Am J Obstet Gynecol. American College of Obstetricians and Gynecologists. ACOG practice bulletin. Management of recurrent pregnancy loss. Number 24, February Replaces Technical Bulletin Number , September Poston L, Raijmakers MT.
Trophoblast oxidative stress, antioxidants and pregnancy outcome--a review. BAX pro-apoptotic gene alterations in repeated pregnancy loss. Arch Med Sci. Tricalcium phosphate is a concentrated form of calcium that some people take as a supplement when they are not getting enough calcium from their diet…. L-5 hydroxytryptophan 5-HTP is a naturally occurring compound in the body. It is related to the production of serotonin, so some people think that….
What are the benefits of NAC? Medically reviewed by Adithya Cattamanchi, M. Benefits Risks Summary We include products we think are useful for our readers. Share on Pinterest NAC may help manage symptoms of bipolar disorder. Exposure to air pollutants may amplify risk for depression in healthy individuals. Costs associated with obesity may account for 3.
Related Coverage. Benefiber vs. Metamucil: Which is better? Medically reviewed by Alan Carter, PharmD. Does magnesium relieve migraines? Medically reviewed by Lindsay Slowiczek, PharmD. That is being investigated now. Stay tuned, and I will keep you updated. Until then, eat lots of broccoli, cauliflower, and asparagus. FDA website. Accessed Jan. Cumberland Pharmaceuticals Inc. Product Information: acetylcysteine inhalation solution, acetylcysteine inhalation solution. American Regent, Inc.
Institute of Medicine. Food and Nutrition Board. January 11, Gunda Siska, PharmD.
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