Because of other factors that could affect the pregnancies exposed to ondansetron, it is not known if ondansetron actually increases the chance of birth defects. Studies did not find a higher chance of pregnancy loss, preterm delivery delivery before 37 weeks of pregnancy , or low birth weight when ondansetron was used during pregnancy.
At higher doses, there have been reports that ondansetron use might cause a heart rhythm problem called QT interval prolongation in the person taking ondansetron. In severe cases, this could become an abnormal heart rhythm known as Torsades de Pointes.
If you are taking ondansetron, you can talk to your healthcare provider about how to watch for changes in your heart rhythm. Does taking ondansetron in pregnancy cause long-term problems in behavior or learning for the baby? One study looked at 78 infants who were exposed to ondansetron at any time during pregnancy. The infants were looked at between 7 days to 2 months of age and did not show any signs of unusual behaviors. A single follow-up survey for about 25 of these children was sent in by the parents.
The survey asked about behavior. The surveys did not report behavior differences in these children compared to children who were not exposed ondansetron during pregnancy. There are no other studies looking at the use of ondansetron in pregnancy and long-term effects for the baby.
There have been no studies in humans looking at the use of ondansetron during breastfeeding. Studies in animals suggest that ondansetron enters breast milk, but the effects of ondansetron on a breastfeeding infant are not known. If ondansetron use is necessary, it is not usually a reason to stop breastfeeding. The researchers found an increase in oral clefts, but this association was less precisely estimated confidence interval 1.
The researchers found an absolute risk of The team also examined information on congenital malformations overall, finding no increased risk among fetuses exposed to the drug during the first trimester. The jump in vaping was the largest one-year increase for any substance in the year history of the survey. Skip to content The Harvard Gazette Study sees little danger from ondansetron during first trimester of pregnancy Teen vaping rising fast, research says.
Credit: pixabay. While these data may raise some concerns, suggesting the possibility of a very small increase in absolute risk, many women experience severe nausea and vomiting which can interfere with functioning. Furthermore, early treatment of nausea and vomiting of pregnancy is recommended to prevent progression to hyperemesis gravidarum. From a mental health perspective, we also see that prolonged NVP, especially when severe, can lead to increased anxiety and depressive symptoms.
Andrade C. J Clin Psychiatry. Free Article. Erick M, et al. Obstet Gynecol. Previous Next. View Larger Image.
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